Prison Break star Sarah Wayne Callies has claimed a male co-star on the hit drama once spat in her face during filming in a shocking new interview.

Callies, 46, who played Sara Tancredi in the Fox show from 2005-2017 – claimed there was ‘rampant misogyny on set’ as she reflected on her time on the predominately male-led show in a chat on Rachel Bilson’s Broad Ideas podcast.

Callies said: ‘I mean, like, I’ve had an actor on that show spit in my face. And I was like, “Holy s***.”‘

The star did not name the actor on the show – which starred her onscreen husband Wentworth Miller and Dominic Purcell – and said ‘some of the guys were great, and some of them were totally gentlemen’ but due to their dizzying rise to fame, drama unfolded.

She added that she will ‘talk about it someday’ on her own rewatch podcast, Prison Breaking – and said: ‘ There were things. Like, I would go home some nights and have to spend an hour talking my husband out of going to hospitalize somebody.’

The star said her podcast had given her  ‘the sort of medicine to go back’ and appreciate the show, despite ‘the rampant misogyny, despite all of the challenges’ as ‘the only woman around.’

Callies had doubts over rewatching the show, saying ‘because I didn’t want it to send me into a spiral of, like, “What did I let them do to me? What did I let them say to me? What did I put up with? What did I not report?’

She added: ‘So much of it was also great and [I] made lifelong friends’ while saying she ‘didn’t have scenes with women’ on the show which was a ‘missed opportunity’.

DailyMail.com has contacted representatives for Fox for comment.

Prison Break ran for five seasons with the first four airing between 2005 and 2009, before it was revived in 2017 for another outing.

The gritty drama focused on Michael Schofield’s (Miller) plan to help Lincoln Burrows (Purcell) escape prison after he was sentenced to death for a crime he did not commit.

Season five was a sequel set seven years after the original show, and saw Michael return from the dead as he fought to get his identity back and take down Poseidon, the person responsible for his disappearance.

The limited series ended with Michael refusing to join the CIA so that he could live a normal life with his wife Sara (Sarah Wayne Callies) and their son Mike.

In 2020 Miller announced he would not return for a sixth season as he doesn’t ‘want to play straight characters’ anymore.

Taking to Instagram to discuss trolling he has received on social media about his sexuality, the actor slammed those with ‘Stone Age values’ for hitting out at him for being gay.

While he does get ‘affectionate’ and ‘supportive’ messages from fans, Wentworth felt the negative trolling he’d received proved it was even more important for him to tell queer stories rather than return to the role of Scofield.

He wrote: ‘On a related note… I’m out. Of PB. Officially. Not bec of static on social media (although that has centered the issue).

‘I just don’t want to play straight characters. Their stories have been told (and told). So. No more Michael.

‘If you were a fan of the show, hoping for additional seasons… I understand this is disappointing. I’m sorry.

‘If you’re hot and bothered bec you fell in love with a fictional straight man played by a real gay one… That’s your work. – W.M.’

Purcell shared his support for Wentworth’s decision, saying in the comments: ‘It was fun mate. What a ride it was.

‘Fully support and understand your reasoning. Glad you have made this decision for you health and your truth. Keep the posts coming. …. love ya brother.’

Responding to the heartfelt message with one of his own, Wentworth said: ‘Thanks, brother. Love you too. Onward.’